Common side effects with short-term use of corticosteroids include increased blood sugar, water retention, acne, weight gain, anxiety, and difficulty sleeping. A temporary rise in energy may be experienced, along with an exaggerated feeling of happiness. Some individuals, however, may feel depressed. Long-term use is not recommended and can cause significant side effects, such as osteoporosis, decreased wound healing, and an increased risk of infections.

Common side effects associated with Acthar Gel include infections, increased blood pressure, irritability, changes in appetite and weight, as well as digestive problems. During plasmapheresis, a drop in blood pressure or fainting may occur. IVIG has a few rare but severe side effects.